Clinical and experimental lymphomagenesis models

Research topics & objectives

Studying the transformations mechanisms of T lymphocytes at the origin of T-cell lymphomas, using functional genomics and cellular biology approaches, evaluated on cell lineages and human samples as well as dedicated mouse models. Characterising the genomic alterations of new B-cell lymphoma sub-types to define new diagnostic and prognostic markers. Studying the resistance mechanisms to inhibitors of the BCR pathway in B-cell lymphomas. Studying metabolic de-regulations in different lymphoma sub-types.

Research topics

  • T-cell lymphomas: functional genomics, new mouse models, TCR signalling role.
  • B-cell lymphomas: molecular and cellular characterisation of lymphomas in the marginal zone, follicular lymphomas and lymphomas of the CNS.
  • The impact of molecular alterations of B and T-cell lymphomas on sensitivity to new anti-cancer agents and on patients’ evolution.

Lymphoma sub-types

  • B-cell lymphomas.
  • T-cell lymphomas.

Key words

T and B-cell lymphomas, TCR signalling, BCR signalling, metabolomics.

Gilles Salles
Gilles Salles Manager
Laurent Genestier Innovation Lymphome
Laurent Genestier Co-manager
Lymphomes B Diffus à grandes cellules
Expertise

Expertise

BIOLOGICAL TARGETS AND IN VITRO/IN VIVO/EX VIVO MODELS

Targets

  • TCR and TCR signalling
  • Cell metabolism

Models

  • B and T cell lineages (modification by CRISPR/Cas9)
  • T-cell lymphomagenesis mouse models

BLOOD AND TISSUE BIOMARKERS

  • SNP, transcriptomics, mutations
  • Attac-Seq

EARLY ACTIVITY PHARMACODYNAMIC SIGNALS

Cytof

TOOLS, PROCESSES AND PLATFORMS LINKED TO THE CLINICAL RESEARCH

Tight links to LYSA clinical trials

INNOVATING TECHNOLOGY

  • CRISPR-Cas9
  • Attac-Seq

Platforms & technical resources

  • Cellular and molecular biology
  • Flow cytometry
  • Cytof

R&D offer

The laboratory offers in vitro and in vivo collaborative research projects on the TCR and BCR signalling pathways and on T-cell lymphoma models (drug efficacy, action mechanism) from human cell lineages and original mouse models.