Metabolism, cancer and immune responses

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Research topics

The team is studying the importance of the energetic metabolism in the development and response of B-cell lymphomas and angioimmunoblastic T cell lymphomas subject to chemotherapeutic treatments and to treatments with metabolic inhibitors.

OBJECTIVES

Determining if the targeting of the energetic metabolism represents a therapeutic option for patients suffering from a certain type of B or T-cell lymphoma and presenting a resistance to current treatments.

KEY WORDS

Diffuse large B-cell lymphomas (DLBCL), Angioimmunoblastic T-cell lymphomas (AITL), energetic metabolisms, glycolysis, mitochondrion, metabolic inhibitor, biomarker.

Jean-Ehrland RICCI membre de l'Institut Carnot CALYM
Jean-Ehrland RICCI Directeur de Recherche

C3M – Inserm U1065

Centre Méditerranéen de Médecine Moléculaire

“Details make perfection, and perfection is not a detail”

 Leonardo Da Vinci
EXPERTISE

Targets

  • Glycolysis pathway
  • Mitochondrial metabolism
  • Amino acid pathway
  • Lipid pathway

Models

  • In vitro: human lineages of diffuse large B-cell lymphomas
  • Non-frozen samples from patients for which there is a suspicion of lymphoma development
  • Mouse model of a non-Hodgkin B-cell lymphoma
  • Humanised mouse

Tissue biomarker

Prognostic biomarker of the response to R-CHOP as well as of the metabolic state of a patient suffering from B-cell lymphoma.

Innovating technologies

  • Metabolomics and carbon tracing
  • Metabolism studies (Seahorse, metabolite production/consumption measurement…)
  • Development of viral tools to transduce T and B stem cells

Platforms and technical resources

TOP 5 of the latest scientific publications (basic research and clinical research):

Calym 2019_GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism. Cancer Cell.
Mondragón L, Mhaidly R, De Donatis GM, Tosolini M, Dao P, Martin AR, Pons C, Chiche J, Jacquin M, Imbert V, Proïcs E, Boyer L, Doye A, Luciano F, Neels JG, Coutant F, Fabien N, Sormani L, Rubio-Patiño C, Bossowski JP, Muller F, Marchetti S, Villa E, Peyron JF, Gaulard P, Lemonnier F, Asnafi V, Genestier L, Benhida R, Fournié JJ, Passeron T, Ricci JE#, Verhoeyen E#. # co-senior and co-corresponding author,
Cancer Cell. 2019 Sep 16;36(3):268-287.e10. Learn more
Calym 2019_GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors. Cell Metab
Chiche J, Reverso-Meinietti J, Mouchotte A, Rubio-Patiño C, Mhaidly R, Villa E, Bossowski JP, Proics E, Grima-Reyes M, Paquet A, Fragaki K, Marchetti S, Briere J, Ambrosetti D, Michiels JF, Molina TJ, Copie-Bergman C, Lehmann-Che J, Peyrottes I, Peyrade F, de Kerviler E, Taillan B, Garnier G, Verhoeyen E, Paquis-Flucklinger V, Shintu L, Delwail V, Delpech-Debiais C, Delarue R, Bosly A, Petrella T, Brisou G, Nadel B, Barbry P, Mounier N, Thieblemont C, Ricci JE.
Cell Metab. 2019 Jun 4;29(6):1243-1257.e10. Learn more
Calym Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance. Cell Metab
Rubio-Patiño C, Bossowski JP, De Donatis GM, Mondragón L, Villa E, Aira LE, Chiche J, Mhaidly R, Lebeaupin C, Marchetti S, Voutetakis K, Chatziioannou A, Castelli FA, Lamourette P, Chu-Van E, Fenaille F, Avril T, Passeron T, Patterson JB, Verhoeyen E, Bailly-Maitre B, Chevet E, Ricci JE.
Cell Metab. 2018 Apr 3;27(4):828-842.e7. Learn more
Calym Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells. Cell Rep
Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier RM, Chiche J, Mondragón L, Riley JS, Marchetti S, Verhoeyen E, Tait SWG, Ricci JE.
Cell Rep. 2017 Sep 19;20(12):2846-2859. Learn more

Contact details

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Contact details

Calym
Centre Hospitalier Lyon-Sud Bâtiment 2D - 69495 PIERRE-BÉNITE Cedex

Contact details

Lysarc
Centre Hospitalier Lyon-Sud Bâtiment 2D - 69495 PIERRE-BÉNITE Cedex

Contact details

Lysa
Centre Hospitalier Lyon-Sud Bâtiment 2D - 69495 PIERRE-BÉNITE Cedex