Regulation of Bcl2 and p53 networks in Multiple Myeloma and Mantle Cell Lymphoma

Research Objectives and Themes

We are working on identifying vulnerabilities that are consequent to the adaptation of cancer cells to survival/resistance and resistance within their ecosystem. At the molecular level, we are focusing on major pathways involved in resistance/escape of cancer cells to deaths, such as p53 pathway and BCL2 network.

Hemopathy B subtypes

Multiple Myeloma and Mantle Lymphoma

Keywords

BCL2 family, p53 network, Microenvironment

Catherine Pellat-Deceunynck
Catherine Pellat-Deceunynck DR CNRS, Team leader
Martine Amiot Co-director of the team
David Chiron CALYM
David Chiron Co-director from 2022
Steven Le Gouill PU-PH Head of the Hematology department, Nantes Hospital

“Our integration into the Calym consortium in 2015 allowed us to significantly increase our interactions with French teams specialized in the field of haemato-oncology and more particularly B Lymphomas. This Carnot network offers great visibility and numerous opportunities, both at the technological and scientific levels but also at the level of research partnership and valorisation. ”

Catherine Pellat-Deceunynck DR CNRS, Directrice de l’équipe

Expertise

  • Large annotated LCM and MM cohorts (biology and clinic)
  • Deep sequencing on single cells (SIRIC ILLIAD)
  • Bioinformatic analyzes of bulk and single cell RNA-seq data
  • CRISPR / CAS9 technology
  • Development of 2D / 3D models ex vivo and PDX in vivo
  • Multiplexed IHC
  • BH3-mimetic toolkits
  • Multiparametric analyzes of immune populations by flow cytometry
MantleCellLymphoma
Technical platforms and resources:

  • Thera-HeMA http://www.therassay.com/services/onco-hematologie/
  • Cytocell platform: flow cytometry and cell sorting Biogenouest (SFR François Bonamy)
  • Bioinformatics and genomics GenoBIRD (Infrastructure of Genomics and Bioinformatics)