Research Objectives and Themes
We are working on identifying vulnerabilities that are consequent to the adaptation of cancer cells to survival/resistance and resistance within their ecosystem. At the molecular level, we are focusing on major pathways involved in resistance/escape of cancer cells to deaths, such as p53 pathway and BCL2 network.Hemopathy B subtypes
Multiple Myeloma and Mantle Lymphoma
Keywords
BCL2 family, p53 network, Microenvironment
Catherine
Pellat-Deceunynck
DR CNRS, Team leader
Martine
Amiot
Co-director of the team
David
Chiron
Co-director from 2022
“Our integration into the Calym consortium in 2015 allowed us to significantly increase our interactions with French teams specialized in the field of haemato-oncology and more particularly B Lymphomas. This Carnot network offers great visibility and numerous opportunities, both at the technological and scientific levels but also at the level of research partnership and valorisation. ”
DR CNRS, Directrice de l’équipeExpertise
- Large annotated LCM and MM cohorts (biology and clinic)
- Deep sequencing on single cells (SIRIC ILLIAD)
- Bioinformatic analyzes of bulk and single cell RNA-seq data
- CRISPR / CAS9 technology
- Development of 2D / 3D models ex vivo and PDX in vivo
- Multiplexed IHC
- BH3-mimetic toolkits
- Multiparametric analyzes of immune populations by flow cytometry
Technical platforms and resources:
- Thera-HeMA http://www.therassay.com/services/onco-hematologie/
- Cytocell platform: flow cytometry and cell sorting Biogenouest (SFR François Bonamy)
- Bioinformatics and genomics GenoBIRD (Infrastructure of Genomics and Bioinformatics)