RedTalks #1: Lymphoma Sugarcoated acces replay
"Metabolism and lymphomas: from basic to translational research"
Speaker: Jean-Ehrland RICCI, Inserm
Moderator: François Lemmonier, APHP
The increased dependence for glycolysis (Warburg effect) is a common feature of most malignant tumors and is hypothesized to be a key step in tumorigenesis. However, the field of cancer metabolism is rooted in the observation that cancer cells exhibit the Warburg effect in vitro. This has misled many to believe that mitochondrial metabolism is either dispensable or only a minor metabolic pathway in tumor growth. Not surprisingly more and more studies are describing the poor consistency observed between in vitro models and patients response to metabolic inhibitors.
During this presentation we will discuss the importance of targeting mitochondrial function in a subset of diffuse large B cell lymphoma (DLBCL) using in vivo models, clinical samples and finally in clinical settings. We will also discuss an innovative pre-clinical model of a rare peripheral T cell lymphoma: Angioimmunoblastic T cell lymphoma (AITL), that allows a better understanding of this pathology and the identification of novel therapeutic options for this still incurable disease.