RedTalks#2 : Why AI hype should not make us lose common sense? Access replay

Speaker: Jean-Ehrland RICCI, Inserm

Moderator: François Lemmonier, APHP

Increased dependence on glycolysis (Warburg effect) is a common feature of most malignancies and is thought to be a key step in tumorigenesis. However, the field of cancer metabolism is rooted in the observation that cancer cells exhibit the Warburg effect in vitro. Thus it is often believed that mitochondrial metabolism is either dispensable or only a minor metabolic pathway in tumor growth. Not surprisingly, more and more studies describe the poor consistency observed between in vitro models and patient response to metabolic inhibitors.

In this presentation, we will discuss the importance of targeting mitochondrial functions in a subset of diffuse large B-cell lymphoma (DLBCL) using in vivo models, clinical samples and finally in the clinical setting. We will also discuss a novel preclinical model of a rare peripheral T-cell lymphoma: angioimmunoblastic T-cell lymphoma (AITL), which allows a better understanding of this pathology and the identification of new therapeutic options for this still incurable disease.

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