RedTalks#3 : “Genetics proposes, Epigenetics disposes”. But it’s all in the genes…

"Genetics-driven epigenetic dysfunction in germinal center derived B cell lymphomas"

Date : Thursday December 3rd at 6pm CET

Panelist : Laura Pasqualucci – Pathology and Cell Biology, Columbia University, New York, NY, USA

Publications: Immunol Rev., Immunity, Cancer Discovery, J Exp. Med.

Modérateurs: Sandrine Roulland UMR7280-U1104-CIML et Karin Tarte UMR U1236-MICMAC

Dr. Pasqualucci’s research interests focus on the molecular pathogenesis of B cell malignancies, with emphasis on its most common types, diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). The laboratory takes advantage of genomic profiling approaches and genetically modified mouse models to identify and functionally characterize the genetic lesions that are associated with these cancers, as a tool to better understand the mechanisms that are responsible for the initiation and maintenance of the tumor cell. The ultimate goal is to develop improved biomarkers and more effective treatment options for lymphoid malignancies.

In this RedTalk, Dr. Pasqualucci will discuss the unique link between the physiologic germinal center reaction and the pathogenesis of B cell lymphomas, and illustrate how genetic alterations in epigenetic modifier genes contribute to the making of these tumors, and present potential therapeutic implications.

Laura Pasqualucci

Laura Pasqualucci

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