What are CAR T-cells?

DESCAR-T, National Registry for Patients with Hematological malignancies, Eligible for CAR T-Cell Therapy

What are CAR T-cells?

“CAR T-cells” stands for Chimeric antigen receptor T-cells.

Based on the principle of treatment individualization, CAR T-cells are Advanced Therapy Medicinal Products (ATMP) and more precisely gene therapies that show great potential to treat some types of hematological malignancies. These therapies use cells that have been genetically modified to express a new receptor on their surface allowing to attack the cancer cells using the patient’s own immune system.

CAR T-cells represents a real hope in the treatment of some types of refractory or relapsed blood cancers.

How are CAR T-cells made?

The manufacturing process for this immunotherapy begins with the collection of a patient’s own T lymphocytes (or T-cells). This step is called leukapheresis. T-cells are white blood cells whose role is to identify and destroy any abnormal cell (e.g., cancer cells) or cells infected by foreign organisms (e.g., bacteria, viruses).

Once collected, and after a quality control, these T-cells are sent to a specialized laboratory to undergo a genetic modification in order to express a new chimeric protein at their surface. This chimeric protein is a particular receptor that will allow these modified T-cells to recognize and attack the cancer cells in the body, once these have been reinjected into the patient.

This is a personalized treatment for each patient to fight their cancer.

Qualified centers for the delivery of CAR-T treatment

In order to be able to offer this therapeutic option, healthcare facilities must be authorized to store and manipulate genetically modified cells, but also to take care of patients who have received these treatments that sometimes cause serious adverse reactions in the days following their administration.

Healthcare facilities willing to deliver CAR-T treatments to their patients must receive a specific qualification.

Currently, there are about 35 approved centers across France.

Qualified centers for the administration of CAR-T treatment in adults

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1. Hôpital Henri Mondor Créteil APHP 51 Avenue du Maréchal de Lattre de Tassigny
94010 Créteil

2. Hôpital Saint-Louis Paris APHP 1 Avenue Claude Vellefaux
75010 Paris

3. Hôpital Lyon-Sud HCL 165 Chemin du Grand Revoyet
69310 Pierre-Bénite

4. Institut d’Hématologie de Basse Normandie Avenue de la Côte de Nacre
14000 Caen

5. IUCT Oncopole 1 Avenue Irène Joliot-Curie
31100 Toulouse

6. Centre Henri Becquerel 1 Rue d'Amiens
76000 Rouen

7. CHU Limoges 2 Avenue Martin Luther King
87000 Limoges

8. Hôpital de la Pitié-Salpêtrière APHP 47-83 Boulevard de l'Hôpital
75013 Paris

9. CHRU Lille 2 Avenue Oscar Lambret
59000 Lille

10. CHU Dijon 14 Rue Paul Gaffarel
21079 Dijon

11. CHU Nancy Rue du Morvan
54500 Vandœuvre-lès-Nancy

12. Institut Paoli-Calmettes Marseille 232 Boulevard de Sainte-Marguerite
13009 Marseille

13. Institut de Cancérologie Strasbourg Europe (ICANS) 1 Place de L Hôpital
67000 Strasbourg

14. Hôpital Necker Paris APHP 149 Rue de Sèvres
75015 Paris

15. CHU Poitiers 2 Rue de la Milétrie
86021 Poitiers

16. CHU Rennes 2 Rue Henri le Guilloux
35000 Rennes

17. Institut Gustave Roussy 114 Rue Edouard Vaillant
94800 Villejuif

18. CHU Amiens Picardie 30 Avenue de la Croix Jourdain
80000 Amiens

19. CHU Angers 4 Rue Larrey
49100 Angers

20. CHU Besançon 3 Boulevard Alexandre Fleming
25000 Besançon

21. CHU Grenoble Boulevard de la Chantourne
38700 La Tronche

22. Institut de Cancérologie et d’Hématologie Universitaire de Saint-Étienne (I.CHU.SE) 108b Avenue Albert Raimond
42270 Saint-Priest-en-Jarez

23. CHU Tours 2 Boulevard Tonnellé
37000 Tours

24. CHU Montpellier 80 Avenue Augustin Fliche
34090 Montpellier

25. CHU Nantes 5 Allée de l'Île Gloriette
44000 Nantes

26. Hôpital Saint-Antoine APHP 184 Rue du Faubourg Saint-Antoine
75012 Paris

27. CHU Bordeaux Avenue Magellan
33600 Pessac

28. CHU Nice 30 Voie Romaine
06000 Nice

29. CHU Clermont-Ferrand 1 Rue Lucie et Raymond Aubrac
63100 Clermont-Ferrand

Qualified centers for the administration of CAR-T treatment in pediatric popultations

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1. Hôpital Saint-Louis Paris APHP 1 Avenue Claude Vellefaux
75010 Paris

2. CHU Poitiers 2 Rue de la Milétrie
86021 Poitiers

3. CHU Montpellier 80 Avenue Augustin Fliche
34090 Montpellier

4. CHU Nantes 5 Allée de l'Île Gloriette
44000 Nantes

5. Hôpital de la Timone 264 Rue Saint-Pierre
13005 Marseille

6. Hôpital Universitaire Robert Debré (Pédiatrie) 48 Boulevard Sérurier
75019 Paris